For me, the key to winning on All Madden level is noticing what the defense is in. Having your audibles set up in the same formation. Example, my favorite formation is the I-formation, so, I have 2 audibles set up, one pass and one run, that I can switch to. Also, noticing when the LB's blitz and drop into coverage is another way to really help yourself out.
Also, when you are in 3+ receiver sets, look for when the CPU puts a linebacker on your 3rd receiver. Having your fastest WR as your 3rd receiver is also a good.
