The thing i find annoying is on a kickoff in the 4th quarter, if you are leading by just a couple of points, the camera does a head on shot of the kicker and follows the ball downfield, which means that you cant see what guy you are controlling or what direction you are running in. This all means that your guy is running in the wrong direction and therefore misses a vital tackle.

Also when you are on defence and you have something like triple coverage on a reciever, the QB lobs the ball up to him and all 3 DBs miss their 'pat downs' and the reciever makes the catch, wouldnt happen in real life.

Holding/facemask penalties should be eradicated, or if not then the player should have the option to do either of these things during a play to see if they can get away with it. i find it really annoying to be called for a penalty that i have no control over.

When playing at Lambeau field all touchdown scorers should do the Lambeau leap

Every team should have the option in their playbook for a HB pass, for example the Chargers do it in real life but it isnt in their playbook in the game.

QBs shouldnt just lob the ball up in the air miles away from the intended reciever, even randy moss cant reach half of them.